Welcome to the KocerLab

We are an interdisciplinary group, which is interested in exploring the working mechanism of membrane proteins and in their potential applications to solve societal problems. Much of work focused on bacterial mechanosensitive ion channels.

financial support

Prof. Ben Feringa wins Nobel Prize 2016 in Chemistry! We wish him many more years of exciting science!

News from the lab

June 2017

  • Prof. A. Kocer will give an invited NCCR TransCure Lecture in Physiology at the University of Bern, Institute of Biochemistry and Molecular Medicine (IBMM). The lecture will be about (1) our molecular tools to study and manipulate ion channels in their detergent- solubilized form, liposomes, cells, and vacuum environment, (2) findings on the working mechanism of a mechanosensitive ion channel at the molecular level, and (3) how this background is applied to understand the structure and function of a human ion channel, which is involved in both spinocerebellar ataxia and sudden cardiac arrest. The talk will end with two direct applications of our engineered ion channels in the fields of nanomedicine and biosensors, especially on targeted and triggered drug delivery and early disease diagnosis.
  • Based on her pre-proposal, Prof. A. Kocer is invited to send a full proposal for The Netherlands Organisation for Scientific Research (NWO)- Innovational Research Incentives Scheme Vici Grant (NWO-Vici). This is an individual grant targeting at outstanding senior researchers, giving the opportunity to build up their own research group.
  • Master students Sambit Das and Anisa Nurani and the PhD student Claudio Tiecher presented 3 posters in Dutch Neuroscience 2017 Meeting in Lunteren. The titles of the posters were: “Heterologous expression of AMPA receptors in Pichi pastoris”, “Voltage-gated potassium channel Kv4.3 in polymer nanodiscs”, and “In vivo site-specific labelling of Kv4.3 for structure-function studies: prospects on understanding the neurodegenerative disorder spinocerebellar ataxia 19/22 at the molecular level”.

March 2017

  • Our review paper “Drug delivery from engineered organisms and nanocarriers as monitored by multimodal imaging technologies” is published in AIMS Bioengineering (pdf)

January 2017

  • Our collaborative research paper  “High-throughput simulations reveal membrane-mediated effects of alcohols on MscL gating” is accepted for publication in Journal of the American Chemical Society.  The paper reports on the effects of alcohols on the gating of an ion channel. High-throughput coarse-grained molecular dynamics simulations and experimental data showed that short chain alcohols have an impeding effect on the opening threshold of the mechanosensitive channel of large conductance, MscL.
  • Sambit Das and Anisa Nurani joined the Kocerlab for their master projects on AMPA receptors and nanodisks, respectively. We wish them lots of success in their projects.

December 2016

  • Priya Bodha joined the Kocerlab to perform her master project on a viral protein. We wish her lots of success in her studies.

October 2016

  • Prof. A Kocer joined the Editorial Board of Frontiers in Oncology as a Review Editor in Cancer Imaging and Diagnosis.
  • Prof. Dame Carol Robinson is visiting University Medical Center Groningen, University of Groningen. In the second day of her visit to the Netherlands as “The Speaker of the Year 2016” of the Netherlands Society for Biochemistry and Biology (NVBMB), Prof. Robinson will be talking to principle investigators and giving a lecture.

September 2016

  • Our invited research paper  “In situ, Reversible Gating of a Mechanosensitive Ion Channel through Protein-Lipid Interactions ” is published in Frontiers in Physiology (pdf)

August 2016

  • Claudio Tiecher started his five months collaborative project at the  Osaka University under the guidance of Prof. Yasushi Okamura and Dr. Akira Kawanabe. Claudio will be learning modifying ion channels with a genetically encoded environment-sensitive fluorescent probe. His visit is supported by JASSO Scholarship Program through the exchange program between the Graduate School of Medicine, Faculty of Medicine, Osaka University and University Medical Center Groningen, University of Groningen.

June 2016

  • Armagan Kocer organized a session “Ion channels of the nervous system in health and disease” for the Dutch Neuroscience Meeting. A Kocer gave a talk, Marloes Scholten, and Claudio Tiecher presented two posters.
  • Congratulations to Marloes Scholten for successfully defending her Master project on “Cloning and overexpression of Kv4.3-EGFP fusion protein in Pichia pastoris“. We wish her success and pleasure in her second project.
  • Claudio Tiecher presented his work on voltage-gated ion channel Kv4.3 at the European Neuroscience Conference for Doctoral Students

 April 2016

  • Armagan Kocer gave a lecture at “Biophysics of Protein-Lipid Interactions: From Model Systems to Cells” meeting in Bad Herrenalb, Germany. The joint meeting is organized by the Membrane Sections of the French and German Biophysical Societies.